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Title   Cisplatin 병화학요법에 의한 오심 및 구토에서 Ondansetron 과 metoclopramide 의 효과에 대한 비교연구 ( A Prospective Randomized Comparison of Ondansetron and Metoclopramide in the Prophylaxis of Emesis Induced by Cisplatinum Based Combination Chemotherapy )
Publicationinfo   1991 Jan; 023(02): 418-424.
Key_word   Cisplatin, Emesis, Ondansetron
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Abstract   Sixty solid tumor patients who are scheduled to receive cisplatinum containing combination chemotherapy participated in a prospectively randomized study to compare the antiemetic effecacy and safety of ondansetron and metoclapramide. Ondansetron was given as an 8 mg laading dose IV before chemotherapy followed by 8 mg IV every 8 hours for 24 hour period, then switched to 8 mg orally every 8 hours for another 5 days. Metoclopramide was given as an 1 mg/kg loading dose IV before chemotherapy followed by same dose every 8 hours for 24 hour period, then 20 mg every 8 hours orally for another 5 days. Complete or major control (zero to 2 emetic episodes) of emesis was achieved in 25 of 30 (83.3%) patients receiving ondansetron and in 13 of 30 (43.3%) patients receiving metoclopramide (p<0.001). Ondansetron was also more effective in reducing acute nausea. Extrapyramidal reactions were observed in 1 metoclopramide treated patient. Other unwanted reactions which forced cessation of study were restlessness experienced by 4 metaclopramide patients. No severe side reactions were recorded in ondansetron treated patients, while mild to moderate headache was noted in 20% of patients. These results are in agreement with other studies showing ondansetron's superiority to metoclopramide in controlling acute emesis and nausea.
저 자   정태준(Te June Chung),심승철(Seung Chul Shim),강경원(Kyung Won Kang),최일영(Il Young Choi)